Your natural sleep solution! Unleash the power of melatonin, 5-Hydroxytryptophan, GABA, and Bacopa Monnieri. Sleep peacefully, wake up refreshed, and protect your brain as you age. Embrace a healthier, happier you! Sleep-E Naturals contains natural agents that help improve sleep quality and duration, naturally, without risk of addiction or dependency. It also contains nutrients that help protect the brain against free radical damage, slowing down brain aging. How it Works Melatonin - Melatonin is a hormone normally made by the Pineal gland in the brain that controls our wake/sleep cycles. Upon darkness (late in the evening) the Pineal gland normally secretes enough melatonin to help induce sleep and enable us to reach deep levels of sleep known as delta-sleep (delta-brain waves). This level of sleep recharges the body's immune system and allows us to wake up and function in a refreshed state. In fact, the immune system itself has melatonin receptors. Upon stimulation from melatonin immune cells function at a higher level of proficiency. Melatonin is also an important brain antioxidant, which protects brain cells against free radicals. The brain uses about 20% of the body's oxygen at any given time, which also increases brain exposure to oxygen free radicals. Free radical damage in the brain is associated with dementia and a number of brain and memory-related degenerative conditions. As we age the production of melatonin drops considerably, which often results in a decreased ability to fall asleep and/or interrupted sleep (wake up several times during the night) and/or decreased sleep duration and/or an inability to reach deep levels of sleep. These are common complaints of individuals over the age 40. The lack of melatonin is also associated with decreased immune function and greater susceptibility to certain health conditions as we age. Breast cells and prostate cell also have melatonin receptors, whereby melatonin stimulation of these tissues has been shown to exert important disease protective effects. The melatonin found in Sleep-E Naturals replaces the melatonin your body no longer makes for itself as you age, which can help improve sleep quality and duration, and support immune function, breast and prostate health, when used as part of a healthy aging program. 5-Hydroxytryptophan - The brain manufactures serotonin and melatonin from 5-hydroxytryptophan, which is found naturally in the plant known as the Griffonia Simplicifolia. Studies show that supplementation with 5-hydroxytryptophan can raise brain levels of serotonin (improving feeling of well being and sleep quality) and melatonin, on a per need basis. GABA (Gamma-Amino-Butyric Acid) - GABA is a natural brain chemical that stimulates GABA receptors in the brain. Upon stimulation, GABA receptors create a feeling of relaxation, improved well being and decreased anxiety. GABA works with melatonin and 5-hydroxytryptophan to help improve sleep quality Bacopa Monnieri - The leaf of bacopa, or water hyssop, has been used in the Indian medical system since the 6th century A.D. Its active ingredients (bacosides A and B) have been shown to enhance nerve transmission and are potent antioxidants, which help protect brain cells from free radical damage. Free radical damage to the brain is a common feature of dementia, degenerative neurological diseases, and memory-loss conditions. Along with melatonin, the bacopa monnieri in Sleep-E Naturals provides additional protection against free radical damage to the brain while we sleep and helps support mental acuity as we age. Clinical Applications Insomnia Interrupted sleep common waking up through the night Lack of deep sleep, not waking up refreshed General brain, breast, prostate and immune support after 40 Dosage Insomnia and sleep disturbances - Begin by taking one capsule, one hour before bedtime. If sleep disturbances are not resolved then increase the dosage by one capsule each night until sleep problems are satisfactorily resolved and you are waking up refreshed. If morning drowsiness or headache occurs then reduce the dosage down until sleep disturbances are resolved without morning drowsiness or headache. Do not exceed 6 capsules per night without consent of your attending physician. Typical target dosages by age: - To improve sleep quality and duration, and provide protection to the brain, breast, prostate and immune system: Age 40 - 44: one capsule, one hour before bedtime Age 45 - 50: two capsules, one hour before bedtime Age 51 - 55: three capsules, one hour before bedtime Age 56 - 60: four capsules, one hour before bedtime Age 61 - 65: five capsules, one hour before bedtime Age 66 and older: six capsules, one hour before bedtime Amounts for 1 capsules, 90 per bottle Melatonin <0.5 mg (500 mcg) 5-HTP (5-hydroxytryptophan) 10 mg GABA (Gamma-amino butyric acid) 25 mg Bacopa Monnieri (std to 20% bacosides) 15 mg Sleep-E Naturals contraindications & considerations: Do not take this supplement if you have any of the following health conditions or circumstances listed below if there is no number listed next to it. If a number is listed next to the item below, then adhere to the precautionary note explained in the legend at the bottom of the page.   Conditions Pregnancy Breastfeeding or Lactation Kidney failure (Renal failure) (6) Liver ailments (6) Kidney disease (6)   Medication / Treatment / Apparatus Sleep aid drug / Anti-anxiety drug (6) Anti-depressant drugs (6) Receiving chemotherapy treatment (6) Receiving radiation treatment (6)   Legend (6) - Requires approval from specialist